Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Prostaglandin H2 (PGH2) | 42935-17-1 | ≥95.0% | 352.47 | 10 UG
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Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor that can cause vasoconstriction. It is the common precursor of all prostaglandins and is produced by several cells that express cyclooxygenases. PGH2 can activate PGD2 receptors CRTH2 and DP by interacting directly with the receptors or by giving rise to PGD2 after catalytic conversion by plasma proteins. It is used in research for inflammation and neurological diseases, such as Alzheimer's disease.
- Increases forward-scatter of eosinophils
- Induces shape changes and Ca2+ production in eosinophils
- Induces migration and collagen-induced platelet aggregation in eosinophils
- Inhibits eosinophil degranulation by activation of CRTH2 receptors
- Accelerates the rate of formation of dimers and higher oligomers of amyloid β1-42
- Induces contraction of rabbit pulmonary artery
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Medchemexpress LLC Amikacin (standard) | 37517-28-5 | 99.9% | 200 MG
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Amikacin is a semisynthetic kanamycin analog that is effective against most Gram-negative bacteria, including strains resistant to gentamicin and tobramycin. It exhibits a significant inhibitory effect and can be utilized in bacteriostatic, anti-cancer, and analgesic studies.
- Semisynthetic kanamycin analog
- Effective against most Gram-negative bacteria
- Exhibits significant inhibitory effect
- Can be utilized in bacteriostatic, anti-cancer, and analgesic studies
- Appearance: solid, white to off-white
- Purity: 99.9%
- Molecular weight: 585.60
- Formula: C22H43N5O13
- Recommended storage: 4°C, sealed and dry, away from moisture
- Shipping: room temperature in continental US
- Stable under recommended storage conditions
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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | MFCD00012656 | 99.9% | 500 MG
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Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It is also a potent α1-adrenergic receptor antagonist and a potent NUPR1 inhibitor, exhibiting anticancer activity. Additionally, it acts as a calmodulin inhibitor and inhibits P-glycoprotein. This compound can be used in schizophrenia research and is a reversible inhibitor of influenza virus morphogenesis.
- Antipsychotic agent
- Blocks central dopamine receptors
- Potent α1-adrenergic receptor antagonist
- Potent NUPR1 inhibitor
- Exerts anticancer activity
- Calmodulin inhibitor
- Inhibits P-glycoprotein
- Used for schizophrenia research
- Reversible inhibitor of influenza virus morphogenesis
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Medchemexpress LLC Ranolazine | 95635-55-5 | 99.8% | 200 MG
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Ranolazine (CVT 303) is an anti-angina drug that inhibits the late phase of inward sodium current (INa and IKr) and acts as an antianginal agent. It is also a partial fatty acid oxidation (FAO) inhibitor. This product is for research use only and not sold to patients.
- Inhibits late phase of inward sodium current (INa and IKr)
- Acts as an antianginal agent
- Partial fatty acid oxidation (FAO) inhibitor
- Does not affect heart rate or blood pressure
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568663 DIMENHYDRINATE-200MG
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568613 QUINIDINE-SULFATE-50MG
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Medchemexpress LLC 5(6)-Carboxy-2',7'-dichlorofluorescein | 111843-78-8 | 99.0% | 100 MG
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5(6)-Carboxy-2',7'-dichlorofluorescein is an ideal substrate for MRP2 vesicular transport assay, possessing excellent detection and transport properties.
- Ideal substrate for MRP2 vesicular transport assay
- Excellent detection and transport properties
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Medchemexpress LLC Sulfo-SMCC sodium | 92921-24-9 | 99.9% | 200 MG
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Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker. It contains N-hydroxysuccinimide (NHS) ester and maleimide groups, which allow it to react with primary amines and sulfhydryl groups, respectively. This product is intended for research use only.
- Reacts with primary amines and sulfhydryl groups
- Suitable for ADC conjugation
- Noncleavable linker
- Used in various biological research applications
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eMolecules EMOLECULES INC
5000489094 2-METHOXY-PYRIDINE-4-CARBAL 1G
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Medchemexpress LLC Mpeg-amine (MW 2000) | 80506-64-5 | 99.6% | (C2H4O)nC3H9NO | 50 MG
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mPEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Acts as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Suitable for biochemical assay reagents
- Applicable in drug delivery
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TARGETMOL CHEMICALS INC GANDOTINIB 25MG
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Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50 3 nM) effective in JAK2V617F(Ki 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3. purity: 99%
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 | C19H22N2O | 5g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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Ambeed Methyl 5bromo2fluorobenzoate
Methyl 5-bromo-2-fluorobenzoate, 57381-59-6, 98%
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 250 MG
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Amino-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds employ the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This mechanism involves two distinct ligands, connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other binds to the protein of interest.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Applicable in targeted therapy drug development
- For research use only
- Molecular weight of 456.57
- Store at 4°C, protect from light. In solvent: store at -80°C for 6 months, or -20°C for 1 month (protect from light).
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Medchemexpress LLC Sulfo-LC-SPDP (sodium) | 169751-10-4 | MFCD00083162 | >90.0% | 527.57 | C18H22N3NaO8S3 | 25 MG
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Sulfo-LC-SPDP (sodium) is a water-soluble, cleavable heterobifunctional crosslinker that introduces a reducible disulfide linkage between amine and sulfhydryl groups. It is used as an ADC linker and for protein conjugation in research.
- Water-soluble, cleavable heterobifunctional linker.
- Introduces a reducible disulfide bond for controlled payload release.
- Contains an NHS ester for reaction with primary amines.
- Contains a pyridyldithiol group for reaction with thiols.
- Provided as the sodium salt for improved aqueous solubility.
- Available in small-mass quantities suitable for research-scale conjugation.
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